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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701969
Molecular formulaC18H21ClN2O
IUPAC nameN-[1-(4-chlorophenyl)ethyl]-4-[(2S)-morpholin-2-yl]aniline
Molecular weight316.829
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.6
SynonymsBDBM129428
SCHEMBL12609817
US8802673, 70
Inchi KeyJFIRPSVVFUGHGX-PQJIZZRHSA-N
Inchi IDInChI=1S/C18H21ClN2O/c1-13(14-2-6-16(19)7-3-14)21-17-8-4-15(5-9-17)18-12-20-10-11-22-18/h2-9,13,18,20-21H,10-12H2,1H3/t13?,18-/m1/s1
PubChem CID68325581
ChEMBLCHEMBL3701969
IUPHARN/A
BindingDB129428
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki4066.5 nM, NoneBindingDB,ChEMBL

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