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GPCR

NameSuccinate receptor 1
SpeciesHomo sapiens (Human)
GeneSUCNR1
SynonymP2Y purinoceptor 1-like
G-protein coupled receptor 91
succinate receptor 1
GPR91
succinate receptor
[ Show all ]
DiseaseN/A
Length334
Amino acid sequenceMLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
UniProtQ9BXA5
Protein Data BankN/A
GPCR-HGmod modelQ9BXA5
3D structure modelThis predicted structure model is from GPCR-EXP Q9BXA5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2150838
IUPHAR166
DrugBankBE0002258

Ligand

NameCHEMBL2153447
Molecular formulaC26H25N3O2
IUPAC nameN-[[4-(3-methoxyphenyl)phenyl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide
Molecular weight411.505
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.4
SynonymsBDBM50393124
Inchi KeyJGVSDYAGZPHABS-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H25N3O2/c1-31-24-8-2-5-22(17-24)20-12-10-19(11-13-20)18-28-25(30)9-3-7-23-15-14-21-6-4-16-27-26(21)29-23/h2,4-6,8,10-17H,3,7,9,18H2,1H3,(H,28,30)
PubChem CID71449506
ChEMBLCHEMBL2153447
IUPHARN/A
BindingDB50393124
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501000.0 nMPMID21571530BindingDB,ChEMBL

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