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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL1829146
Molecular formulaC17H15NO2
IUPAC name3-[4-[2-(6-methylpyridin-2-yl)ethynyl]phenyl]propanoic acid
Molecular weight265.312
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.1
SynonymsZINC72118914
BDBM50419173
SCHEMBL1549563
Inchi KeyAVAPGBWGSJATFN-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H15NO2/c1-13-3-2-4-16(18-13)11-9-14-5-7-15(8-6-14)10-12-17(19)20/h2-8H,10,12H2,1H3,(H,19,20)
PubChem CID54757514
ChEMBLCHEMBL1829146
IUPHARN/A
BindingDB50419173
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC506165.95 nMPMID21854074BindingDB,ChEMBL
Efficacy108.0 %PMID21854074ChEMBL

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