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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-C chemokine receptor type 8
Species	Homo sapiens (Human)
Gene	CCR8
Synonym	GPRCY6 GPR-CY6 CMKBRL2 CKR-L1 ChemR1 Chemokine receptor-like 1 CCR8 CCR-8 CC-CKR-8 CC chemokine receptor CHEMR1 C-C CKR-8 TER1 [ Show all ]
Disease	Psoriasis
Length	355
Amino acid sequence	MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
UniProt	P51685
Protein Data Bank	N/A
GPCR-HGmod model	P51685
3D structure model	This predicted structure model is from GPCR-EXP P51685.
BioLiP	N/A
Therapeutic Target Database	T20575
ChEMBL	CHEMBL4596
IUPHAR	65
DrugBank	N/A

Ligand

Name	4,7-Dimethyl-1,10-phenanthroline
Molecular formula	C14H12N2
IUPAC name	4,7-dimethyl-1,10-phenanthroline
Molecular weight	208.264
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.2
Synonyms	AC1L2IOK AX8092960 CS-W004562 FT-0634746 NSC 4281 ST078007 AJ-11702 C-10624 DB-050425 KB-35859 Oprea1_825186 ZB004124 4,7-DIMETHYL-[1,10]PHENANTHROLINE ALBB-023379 DTXSID9062932 MolPort-004-947-232 SBB008716 248D053 AC1Q4W9O BDBM50401348 CTK3J6706 I14-11063 NSC-4281 ST2405277 4,7-dimethyl-1,9-phenanthroline AK-84388 CC-17428 DB02586 KS-00000NVT R2743 ZINC120461 1,10-Phenanthroline, 4,7-dimethyl- 4,7-dimethylpyridino[3,2-h]quinoline 71958-79-7 ANW-13810 CHEMBL593442 EINECS 221-827-5 NCGC00247283-01 SCHEMBL182930 3248-05-3 ACMC-1CJN6 Bis(5-chlorophenyl)acetic Acid D0772 JIVLDFFWTQYGSR-UHFFFAOYSA-N NSC4281 TRA0022341 4,7-Dimethyl-o-phenanthroline AKOS003369115 CD-1248 DS-2431 MFCD00004979 RT-003206 ZX-AN021893 1,10-phenanthroline, 4,7-dimethyl-, hydrate 4CH-018631 [ Show all ]
Inchi Key	JIVLDFFWTQYGSR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H12N2/c1-9-5-7-15-13-11(9)3-4-12-10(2)6-8-16-14(12)13/h3-8H,1-2H3
PubChem CID	72792
ChEMBL	CHEMBL593442
IUPHAR	N/A
BindingDB	50401348
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	501.19 nM	PMID22957890	BindingDB,ChEMBL
EC50	520.0 nM	PMID22957890	BindingDB,ChEMBL
FC	2.6 -	PMID22957890	ChEMBL
Ratio EC50	7.5 -	PMID22957890	ChEMBL

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