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GPCR

NameAlpha-2C adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra2c
Synonymalpha2C-adrenoceptor
alpha2-C4
Alpha-2CAR
alpha-2C adrenoreceptor
Alpha-2C adrenoceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length458
Amino acid sequenceMASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProtP22086
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL314
IUPHARN/A
DrugBankN/A

Ligand

Nametolazoline
Molecular formulaC10H12N2
IUPAC name2-benzyl-4,5-dihydro-1H-imidazole
Molecular weight160.22
Hydrogen bond acceptor1
Hydrogen bond donor1
XlogP2.6
SynonymsIMI037
2-(phenylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride
KBio2_003779
2-BENZYL-4,5-IMIDAZOLINE HCl
MCULE-5694308124
[ Show all ]
Inchi KeyJIVZKJJQOZQXQB-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
PubChem CID5504
ChEMBLCHEMBL770
IUPHAR7310
BindingDB55436
DrugBankDB00797

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki120.0 nMPMID2876905BindingDB
Ki450.0 nMPMID2876905BindingDB
Ki500.0 nMPMID2876905BindingDB
Ki890.0 nMPMID2876905BindingDB

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