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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesRattus norvegicus (Rat)
GeneHtr7
SynonymGPRFO
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
5-HTx
5-HT7 receptor
5-HT7
[ Show all ]
DiseaseN/A for non-human GPCRs
Length448
Amino acid sequenceMMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProtP32305
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3223
IUPHAR12
DrugBankN/A

Ligand

NameCYPROHEPTADINE
Molecular formulaC21H21N
IUPAC name1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine
Molecular weight287.406
Hydrogen bond acceptor1
Hydrogen bond donor0
XlogP4.7
SynonymsPDSP2_001213
BRD-K28143534-003-03-6
Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-
CCG-204341
SPBio_002025
[ Show all ]
Inchi KeyJJCFRYNCJDLXIK-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3
PubChem CID2913
ChEMBLCHEMBL516
IUPHAR277
BindingDB50017721
DrugBankDB00434

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki31.6228 - 79.4328 nMPMID8394362, PMID8397408IUPHAR
Ki33.88 nMPMID7984267BindingDB
Ki34.1 nMPMID8394362BindingDB
Ki47.86 nMPMID7984267BindingDB
Ki48.0 nMPMID8394362BindingDB
Ki50.0 nMPMID10843226BindingDB
Ki50.12 nMPMID10843226, PMID9149537BindingDB,ChEMBL
Ki77.0 nMPMID8397408BindingDB
Ki77.62 nMPMID7984267BindingDB
Ki79.43 nMPMID9149537BindingDB

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