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GLASS

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GPCR

Name	Pituitary adenylate cyclase-activating polypeptide type I receptor
Species	Homo sapiens (Human)
Gene	ADCYAP1R1
Synonym	PACAPR1 pituitary adenylate cyclase activating polypeptide 1 receptor (1) PACAP1-R PACAP-R1 PACAP-R-1 PACAP type IA receptor PACAP type I receptor PACAP receptor 1 PAC1R PAC1 receptor adenylate cyclase activating polypeptide 1 receptor type 1 adenylate cyclase activating polypeptide 1 receptor 1 PVR1 [ Show all ]
Disease	N/A
Length	468
Amino acid sequence	MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
UniProt	P41586
Protein Data Bank	3n94
GPCR-HGmod model	P41586
3D structure model	This structure is from PDB ID 3n94.
BioLiP	BL0183307
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5399
IUPHAR	370
DrugBank	N/A

Ligand

Name	CHEMBL255635
Molecular formula	C22H17ClN4O2
IUPAC name	3-chloro-4-hydroxy-N-[(E)-[1-(pyridin-3-ylmethyl)indol-4-yl]methylideneamino]benzamide
Molecular weight	404.854
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.7
Synonyms	N/A
Inchi Key	AVLPOQAUQDPFJZ-DHRITJCHSA-N
Inchi ID	InChI=1S/C22H17ClN4O2/c23-19-11-16(6-7-21(19)28)22(29)26-25-13-17-4-1-5-20-18(17)8-10-27(20)14-15-3-2-9-24-12-15/h1-13,28H,14H2,(H,26,29)/b25-13+
PubChem CID	44453765
ChEMBL	CHEMBL255635
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	49.0 %	PMID18272364	ChEMBL

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