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Name | 5-hydroxytryptamine receptor 2C |
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Species | Rattus norvegicus (Rat) |
Gene | Htr2c |
Synonym | 5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 460 |
Amino acid sequence | MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV |
UniProt | P08909 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL324 |
IUPHAR | 8 |
DrugBank | BE0004882 |
Name | Mesulergine |
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Molecular formula | C18H26N4O2S |
IUPAC name | (6aR,9S,10aR)-9-(dimethylsulfamoylamino)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline |
Molecular weight | 362.492 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 1.4 |
Synonyms | 2N-[4,7-dimethyl-(6aR,9S,10aR)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl]-2-dimethylaminosulfonamide AB01275438-01 CAS-64795-35-3 D0K5NZ Mesulergina [ Show all ] |
Inchi Key | JLVHTNZNKOSCNB-YSVLISHTSA-N |
Inchi ID | InChI=1S/C18H26N4O2S/c1-20(2)25(23,24)19-13-9-15-14-6-5-7-16-18(14)12(10-21(16)3)8-17(15)22(4)11-13/h5-7,10,13,15,17,19H,8-9,11H2,1-4H3/t13-,15+,17+/m0/s1 |
PubChem CID | 68848 |
ChEMBL | CHEMBL12314 |
IUPHAR | 206 |
BindingDB | 50024204 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.37 nM | PMID12519065 | ChEMBL |
Ki | 0.630957 nM | PMID9282936 | IUPHAR |
Ki | 0.73 nM | PMID10229626, PMID9513601 | ChEMBL |
Ki | 0.9 nM | PMID9928251 | BindingDB |
Ki | 1.0 nM | PMID3139864 | BindingDB |
Ki | 1.585 nM | PMID10543880 | ChEMBL |
Ki | 1.9 nM | PMID9225287, PMID27061981, PMID19954866, PMID21440338, PMID26820556, PMID22133459 | BindingDB,ChEMBL |
Ki | 1.99 nM | PMID7984267 | BindingDB |
Ki | 2.7 nM | PMID9928251 | BindingDB |
Ki | 3.0 nM | PMID1347569 | BindingDB |
Ki | 3.01 nM | PMID7984267 | BindingDB |
Ki | 5.2 nM | PMID7629808 | ChEMBL |
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