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GPCR

NameD(1A) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd1
SynonymD1 receptor
D1A
DADR
dopamine D1 receptor
Dopamine-1A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProtP18901
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL265
IUPHAR214
DrugBankN/A

Ligand

NameCHEMBL303993
Molecular formulaC16H16ClNO
IUPAC name(1S)-6-chloro-2-methyl-1-phenyl-3,4-dihydro-1H-isoquinolin-7-ol
Molecular weight273.76
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP3.8
Synonyms(S)-6-Chloro-2-methyl-1-phenyl-1,2,3,4-tetrahydro-isoquinolin-7-ol
BDBM50038349
ZINC13675794
(1S)-1alpha-Phenyl-2-methyl-6-chloro-1,2,3,4-tetrahydroisoquinolin-7-ol
6-Chloro-2-methyl-1-phenyl-1,2,3,4-tetrahydro-isoquinolin-7-ol
Inchi KeyAVXGCGYACIYZAR-INIZCTEOSA-N
Inchi IDInChI=1S/C16H16ClNO/c1-18-8-7-12-9-14(17)15(19)10-13(12)16(18)11-5-3-2-4-6-11/h2-6,9-10,16,19H,7-8H2,1H3/t16-/m0/s1
PubChem CID10107367
ChEMBLCHEMBL303993
IUPHARN/A
BindingDB50038349
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki6.6 nMPMID3050089, PMID7996543BindingDB,ChEMBL
Ki9.12 nMPMID7996543ChEMBL
Ki1850.0 nMPMID7996543ChEMBL

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