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GPCR

NameNeuropeptide FF receptor 2
SpeciesHomo sapiens (Human)
GeneNPFFR2
SynonymNPFF2 receptor
Neuropeptide G-protein coupled receptor
GPR74
G-protein coupled receptor HLWAR77
G-protein coupled receptor 74
[ Show all ]
DiseaseN/A
Length522
Amino acid sequenceMNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
UniProtQ9Y5X5
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5952
IUPHAR301
DrugBankN/A

Ligand

NameCHEMBL2165922
Molecular formulaC12H20N4
IUPAC name2-[(E)-1-adamantylmethylideneamino]guanidine
Molecular weight220.32
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP1.4
Synonyms1-[1-Adamantylmethyleneamino]Guanidine
BDBM50394976
SCHEMBL17050151
Inchi KeyJQWIROUDWSKVDL-VIZOYTHASA-N
Inchi IDInChI=1S/C12H20N4/c13-11(14)16-15-7-12-4-8-1-9(5-12)3-10(2-8)6-12/h7-10H,1-6H2,(H4,13,14,16)/b15-7+
PubChem CID60168135
ChEMBLCHEMBL2165922
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<10000.0 nMPMID22708927ChEMBL
EC50298.0 nMPMID22708927ChEMBL
EC50301.0 nMPMID22708927ChEMBL
EC502449.0 nMPMID22708927ChEMBL
EC508332.0 nMPMID22708927ChEMBL
EC508860.0 nMPMID22708927ChEMBL
Emax59.0 %PMID22708927ChEMBL
Emax69.0 %PMID22708927ChEMBL
Emax83.0 %PMID22708927ChEMBL
Emax107.0 %PMID22708927ChEMBL
Emax132.0 %PMID22708927ChEMBL
Emax140.0 %PMID22708927ChEMBL

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