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GPCR

NameMetabotropic glutamate receptor 6
SpeciesHomo sapiens (Human)
GeneGRM6
Synonymnob3
nob2
nerg1
mGluR6
mGlu6 receptor
[ Show all ]
DiseaseN/A
Length877
Amino acid sequenceMARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
UniProtO15303
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4573
IUPHAR294
DrugBankN/A

Ligand

Name(RS)-PPG
Molecular formulaC8H10NO5P
IUPAC name2-amino-2-(4-phosphonophenyl)acetic acid
Molecular weight231.144
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP-3.7
Synonyms120667-15-4
2-amino-2-(4-phosphonophenyl)acetic acid
CHEMBL277475
(R,S)-4-phosphonophenylglycine
AC1ND7MS
[ Show all ]
Inchi KeyJRQRKFDFHAPMGQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)
PubChem CID4545574
ChEMBLCHEMBL277475
IUPHAR1406
BindingDB50004881
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC505011.87 nMPMID10336568, PMID11166323IUPHAR
Ki4700.0 nMPMID10893301BindingDB,ChEMBL

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