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GPCR

NameGlucagon-like peptide 1 receptor
SpeciesRattus norvegicus (Rat)
GeneGlp1r
SynonymGLP-1 receptor
GLP-1-R
GLP-1R
glucagon-like peptide 1 receptor
DiseaseN/A for non-human GPCRs
Length463
Amino acid sequenceMAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
UniProtP32301
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5862
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL449327
Molecular formulaC54H52N4O16S2
IUPAC name2,4-bis[3-methoxy-4-(thiophene-2-carbonyloxy)phenyl]-1,3-bis[[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]amino]cyclobutane-1,3-dicarboxylic acid
Molecular weight1077.14
Hydrogen bond acceptor18
Hydrogen bond donor6
XlogP8.3
SynonymsSCHEMBL12216463
CHEMBL2158412
1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(3-methoxy-4-(thiophene-2-carbonyloxy)phenyl)cyclobutane-1,3-dicarboxylic acid
BDBM50260246
CHEMBL2158413
[ Show all ]
Inchi KeyJSLFGFBQFKCNSQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C54H52N4O16S2/c1-51(2,3)73-49(67)55-33-19-13-29(14-20-33)43(59)57-53(47(63)64)41(31-17-23-35(37(27-31)69-7)71-45(61)39-11-9-25-75-39)54(48(65)66,58-44(60)30-15-21-34(22-16-30)56-50(68)74-52(4,5)6)42(53)32-18-24-36(38(28-32)70-8)72-46(62)40-12-10-26-76-40/h9-28,41-42H,1-8H3,(H,55,67)(H,56,68)(H,57,59)(H,58,60)(H,63,64)(H,65,66)
PubChem CID16186241
ChEMBLCHEMBL449327
IUPHARN/A
BindingDB50260246
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50<20000.0 nMPMID22103243BindingDB
EC50370.7 nMPMID22103243BindingDB
EC50846.8 nMPMID22103243BindingDB
EC502730.0 nMPMID17213311BindingDB,ChEMBL
IC50600.0 nMPMID22103243BindingDB
IC501300.0 nMPMID22103243BindingDB
IC501600.0 nMPMID22103243BindingDB
IC503600.0 nMPMID22103243BindingDB
IC504300.0 nMPMID22103243BindingDB
Ki1470.0 nMPMID17213311BindingDB,ChEMBL

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