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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2068743
Molecular formulaC27H30N4O3
IUPAC name[1-(naphthalen-1-ylmethyl)piperidin-2-yl]-[4-(4-nitrophenyl)piperazin-1-yl]methanone
Molecular weight458.562
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.8
SynonymsSR-02000001252
SR-02000001252-1
Inchi KeyAWDXTIULFGSRCC-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H30N4O3/c32-27(29-18-16-28(17-19-29)23-11-13-24(14-12-23)31(33)34)26-10-3-4-15-30(26)20-22-8-5-7-21-6-1-2-9-25(21)22/h1-2,5-9,11-14,26H,3-4,10,15-20H2
PubChem CID53234156
ChEMBLCHEMBL2068743
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<20000.0 nMPubChem BioAssay data setChEMBL

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