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GPCR

NameMuscarinic acetylcholine receptor M4
SpeciesRattus norvegicus (Rat)
GeneChrm4
Synonymcholinergic receptor
cholinergic receptor, muscarinic 4
Chrm-4
HM3
M4 receptor
DiseaseN/A for non-human GPCRs
Length478
Amino acid sequenceMXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProtP08485
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL317
IUPHAR16
DrugBankN/A

Ligand

NameJTTPGMRULUVVEK-UHFFFAOYSA-N
Molecular formulaC13H20N2O3
IUPAC name4-[methyl(4-pyrrolidin-1-ylbut-2-ynyl)amino]-4-oxobutanoic acid
Molecular weight252.314
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP-2.5
Synonyms4-(Methyl[4-(1-pyrrolidinyl)-2-butynyl]amino)-4-oxobutanoic acid #
SCHEMBL9452418
N-Methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]-3-carboxypropanamide
4-[methyl(4-pyrrolidin-1-ylbut-2-ynyl)amino]-4-oxobutanoic acid
ZINC27856729
[ Show all ]
Inchi KeyJTTPGMRULUVVEK-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H20N2O3/c1-14(12(16)6-7-13(17)18)8-2-3-9-15-10-4-5-11-15/h4-11H2,1H3,(H,17,18)
PubChem CID551031
ChEMBLCHEMBL162477
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity>1.0 %PMID2153827ChEMBL
Affinity0.0 %PMID2153827ChEMBL

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