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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesCavia porcellus (Guinea pig)
GeneHTR7
Synonym5-HT-7
5-HT-X
5-HT7
Serotonin receptor 7
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS
UniProtP50407
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5494
IUPHARN/A
DrugBankN/A

Ligand

Nameritanserin
Molecular formulaC27H25F2N3OS
IUPAC name6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
Molecular weight477.574
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP5.2
Synonyms87051-43-2
Tiserton
Ritanserine
Ritanserina
Ritanserinum
[ Show all ]
Inchi KeyJUQLTPCYUFPYKE-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
PubChem CID5074
ChEMBLCHEMBL267777
IUPHAR97
BindingDB50001775
DrugBankDB12693

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki5.01 nMPMID10051134BindingDB
Ki5.01187 nMPMID10051134PDSP
Ki45.7 nMPMID7647964PDSP,BindingDB
Ki50.12 nMPMID9149537BindingDB
Ki190.54 nMPMID7647964PDSP,BindingDB

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