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Name | 5-hydroxytryptamine receptor 2B |
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Species | Homo sapiens (Human) |
Gene | HTR2B |
Synonym | stomach fundus serotonin receptor serotonin receptor 2B 5-HT2F 5-HT-2B 5-HT2B [ Show all ] |
Disease | Psychoses Migraine Irritable bowel syndrome Depression; Cerebral infarction Coronary heart disease [ Show all ] |
Length | 481 |
Amino acid sequence | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV |
UniProt | P41595 |
Protein Data Bank | 5tud, 5tvn, 6drx, 4ib4, 4nc3, 6dry, 6drz, 6ds0 |
GPCR-HGmod model | P41595 |
3D structure model | This structure is from PDB ID 5tud. |
BioLiP | BL0425280, BL0425283, BL0425282, BL0239858, BL0239859, BL0265182, BL0265183, BL0368464, BL0425281, BL0385686,BL0385687, BL0425284, BL0425285, BL0425286, BL0368465, BL0425287 |
Therapeutic Target Database | T31204 |
ChEMBL | CHEMBL1833 |
IUPHAR | 7 |
DrugBank | BE0000393 |
Name | ritanserin |
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Molecular formula | C27H25F2N3OS |
IUPAC name | 6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one |
Molecular weight | 477.574 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 5.2 |
Synonyms | UNII-145TFV465S SR-01000000024 3726AC KBio1_000192 6-(2-(4-(Bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo((3,2-a)pyrimidin-5-one [ Show all ] |
Inchi Key | JUQLTPCYUFPYKE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3 |
PubChem CID | 5074 |
ChEMBL | CHEMBL267777 |
IUPHAR | 97 |
BindingDB | 50001775 |
DrugBank | DB12693 |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 3.0 nM | PMID16469866 | BindingDB |
Ki | 0.4 nM | PMID9459568 | PDSP,BindingDB |
Ki | 0.630957 - 1.99526 nM | PMID15322733, PMID10188965, PMID9459568, PMID10455251 | IUPHAR |
Ki | 1.0 nM | PMID10455251 | PDSP,BindingDB |
Ki | 1.25893 nM | PMID11882920 | PDSP |
Ki | 1.26 nM | PMID11882920 | BindingDB |
Ki | 1.64 nM | PMID9459568 | PDSP,BindingDB |
Ki | 1.73 nM | PMID8632342 | PDSP,BindingDB |
Ki | 2.13796 nM | PMID15322733 | PDSP |
Ki | 2.14 nM | PMID15322733 | BindingDB |
Ki | 5.01 nM | PMID7582481, PMID10821800 | PDSP,BindingDB |
Ki | 5.01187 nM | PMID10821800 | PDSP |
Ki | 6.45 nM | PMID9225287 | PDSP,BindingDB |
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