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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL594737
Molecular formulaC17H22ClN3OS
IUPAC name(2S)-2-(4-chlorophenyl)-N-[5-(dimethylamino)-1,3-thiazol-2-yl]-3,3-dimethylbutanamide
Molecular weight351.893
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.9
Synonyms(S)-2-(4-chlorophenyl)-N-(5-(dimethylamino)thiazol-2-yl)-3,3-dimethylbutanamide
BDBM50305913
Inchi KeyJVYOCTMKSMPLTP-AWEZNQCLSA-N
Inchi IDInChI=1S/C17H22ClN3OS/c1-17(2,3)14(11-6-8-12(18)9-7-11)15(22)20-16-19-10-13(23-16)21(4)5/h6-10,14H,1-5H3,(H,19,20,22)/t14-/m0/s1
PubChem CID46226308
ChEMBLCHEMBL594737
IUPHARN/A
BindingDB50305913
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy112.0 %PMID20005104ChEMBL
IC501600.0 nMPMID20005104BindingDB,ChEMBL

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