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GPCR

NameNeuropeptide FF receptor 1
SpeciesHomo sapiens (Human)
GeneNPFFR1
SynonymGnIH-R
G protein-coupled receptor 147
OT7T022
NPFF1R1
NPFF1 receptor
[ Show all ]
DiseaseN/A
Length430
Amino acid sequenceMEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
UniProtQ9GZQ6
Protein Data BankN/A
GPCR-HGmod modelQ9GZQ6
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZQ6.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5951
IUPHAR300
DrugBankN/A

Ligand

NameCHEMBL2208059
Molecular formulaC24H30N6O4
IUPAC name(2S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(E)-3-(3-hydroxyphenyl)prop-2-enoyl]amino]pentanamide
Molecular weight466.542
Hydrogen bond acceptor5
Hydrogen bond donor6
XlogP0.8
SynonymsN/A
Inchi KeyJWFAHWONYTYVHH-ARZGSZHJSA-N
Inchi IDInChI=1S/C24H30N6O4/c25-22(33)20(15-16-6-2-1-3-7-16)30-23(34)19(10-5-13-28-24(26)27)29-21(32)12-11-17-8-4-9-18(31)14-17/h1-4,6-9,11-12,14,19-20,31H,5,10,13,15H2,(H2,25,33)(H,29,32)(H,30,34)(H4,26,27,28)/b12-11+/t19-,20-/m0/s1
PubChem CID71463253
ChEMBLCHEMBL2208059
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition21.0 %PMID23131340ChEMBL
Inhibition80.0 %PMID23131340ChEMBL

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