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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-3 adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adrb3
Synonym	beta3-adrenoceptor beta3-adrenergic receptor Beta-3 adrenoreceptor Beta-3 adrenoceptor ADRB beta 3-AR atypical beta-adrenoceptor adrenergic receptor Adrb-3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	400
Amino acid sequence	MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
UniProt	P26255
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4031
IUPHAR	30
DrugBank	N/A

Ligand

Name	2964-04-7
Molecular formula	C11H17NO3
IUPAC name	4-[(1S)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
Molecular weight	211.261
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-0.6
Synonyms	1,2-Benzenediol, 4-((1R)-1-hydroxy-2-((1-methylethyl)amino)ethyl)- 4-[(1S)-1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;tartaric acid AKOS016008975 CHEBI:94595 l-Isopropylnoradrenaline NCGC00179436-02 UNII-L628TT009W component JWZZKOKVBUJMES-LLVKDONJSA-N 1,2-Benzenediol,4-[(1S)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]- 70D2X5QMKK BDBM50407518 cid_6852409 Levisoprenalina [INN-Spanish] PDSP2_000675 (S)-4-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,2-diol AC1Q7ABO Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamino)methyl)-, (-)- Isoproterenol, L- LS-42867 SCHEMBL4166 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (R)- 4-[(1s)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol AX8227512 L-Isopropylnorepinephrine PDSP1_000685 ZINC56653 2,3-bis(oxidanyl)butanedioic acid;4-[(1S)-1-oxidanyl-2-(propan-2-ylamino)ethyl]benzene-1,2-diol AB00514694 Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamin)methyl)-, (-)- CTK4G3600 Levisoprenaline [INN:DCF] PDSP2_001099 (+)-Isoproterenol (S)-Isoprenaline AJ-09351 BRN 3203136 KB-211506 NCGC00179436-01 UNII-70D2X5QMKK 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (S)- (9CI) BDBM34652 CHEMBL460574 l-Isoproterenol PDSP1_001115 2,3-dihydroxybutanedioic acid;4-[(1S)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol AC1L1L6N BENZYL ALCOHOL, 3,4-DIHYDROXY-alpha-((ISOPROPYLAMINO)METHYL)-, (+)- Isoproterenol, (+)- Levisoprenalinum [INN-Latin] Proternol L (-)-alpha-(Isopropylaminomethyl)protocatechuyl alcohol [ Show all ]
Inchi Key	JWZZKOKVBUJMES-LLVKDONJSA-N
Inchi ID	InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3/t11-/m1/s1
PubChem CID	5808
ChEMBL	CHEMBL460574
IUPHAR	N/A
BindingDB	34652, 50407518
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	63000.0 nM	PMID7562902	BindingDB,ChEMBL

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