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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL237925
Molecular formulaC17H24N10O2
IUPAC name2-amino-2-methyl-N-[(1S)-2-phenylmethoxy-1-[1-[2-(2H-tetrazol-5-yl)ethyl]tetrazol-5-yl]ethyl]propanamide
Molecular weight400.447
Hydrogen bond acceptor9
Hydrogen bond donor3
XlogP-0.7
Synonyms(S)-N-(1-(1-(2-(1H-tetrazol-5-yl)ethyl)-1H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide
BDBM50222137
Inchi KeyAWORQDVTWQVKQK-CYBMUJFWSA-N
Inchi IDInChI=1S/C17H24N10O2/c1-17(2,18)16(28)19-13(11-29-10-12-6-4-3-5-7-12)15-22-25-26-27(15)9-8-14-20-23-24-21-14/h3-7,13H,8-11,18H2,1-2H3,(H,19,28)(H,20,21,23,24)/t13-/m1/s1
PubChem CID44434119
ChEMBLCHEMBL237925
IUPHARN/A
BindingDB50222137
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50347.0 nMPMID17869100BindingDB,ChEMBL
Ki5000.0 nMPMID17869100BindingDB,ChEMBL

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