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GPCR

Name5-hydroxytryptamine receptor 2B
SpeciesRattus norvegicus (Rat)
GeneHtr2b
Synonymstomach fundus serotonin receptor
serotonin receptor 2B
5-HT-2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
5-HT2F
[ Show all ]
DiseaseN/A for non-human GPCRs
Length479
Amino acid sequenceMASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProtP30994
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL323
IUPHAR7
DrugBankN/A

Ligand

NameCHEMBL111189
Molecular formulaC24H29FN2O2S
IUPAC name5-[2-[4-[4-(4-fluorophenyl)-4-oxobutyl]piperazin-1-yl]ethyl]-6,7-dihydro-5H-1-benzothiophen-4-one
Molecular weight428.566
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.8
SynonymsBDBM50409495
QF-0602B
Inchi KeyAWPTVVFLXLCOBI-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H29FN2O2S/c25-20-6-3-18(4-7-20)22(28)2-1-11-26-13-15-27(16-14-26)12-9-19-5-8-23-21(24(19)29)10-17-30-23/h3-4,6-7,10,17,19H,1-2,5,8-9,11-16H2
PubChem CID10693836
ChEMBLCHEMBL111189
IUPHARN/A
BindingDB50409495
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Kd158.49 nMPMID11754579BindingDB,ChEMBL

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