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GPCR

NameLysophosphatidic acid receptor 2
SpeciesHomo sapiens (Human)
GeneLPAR2
Synonymendothelial differentiation gene 4, lysophosphatidic acid G-protein-coupled receptor 4
LPA receptor 2
LPA-2
Edg4
Lysophosphatidic acid receptor Edg-4
[ Show all ]
DiseaseN/A
Length351
Amino acid sequenceMVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
UniProtQ9HBW0
Protein Data BankN/A
GPCR-HGmod modelQ9HBW0
3D structure modelThis predicted structure model is from GPCR-EXP Q9HBW0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3724
IUPHAR273
DrugBankN/A

Ligand

NameCHEMBL2335050
Molecular formulaC21H44NaO5PS
IUPAC namesodium;(2-heptadecoxy-3-methoxypropoxy)-hydroxy-oxido-sulfanylidene-lambda5-phosphane
Molecular weight462.602
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogPNone
SynonymsN/A
Inchi KeyJZDLPGVYJPWQNT-UHFFFAOYSA-M
Inchi IDInChI=1S/C21H45O5PS.Na/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-25-21(19-24-2)20-26-27(22,23)28;/h21H,3-20H2,1-2H3,(H2,22,23,28);/q;+1/p-1
PubChem CID71718248
ChEMBLCHEMBL2335050
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC50117.0 nMPMID23395664ChEMBL
EC50117.49 nMPMID23395664ChEMBL
Intrinsic activity0.3 -PMID23395664ChEMBL

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