You can:
Name | Beta-1 adrenergic receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | ADRB1 |
Synonym | Adrenergic receptor beta 1 Adrb-1 ADRB1R adrenergic receptor beta 1-AR [ Show all ] |
Disease | Heart failure; Cardiogenic shock Heart failure Glaucoma Diabetes Coronary artery disease [ Show all ] |
Length | 477 |
Amino acid sequence | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV |
UniProt | P08588 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08588 |
3D structure model | This predicted structure model is from GPCR-EXP P08588. |
BioLiP | N/A |
Therapeutic Target Database | T44068 |
ChEMBL | CHEMBL213 |
IUPHAR | 28 |
DrugBank | BE0000172 |
Name | pindolol |
---|---|
Molecular formula | C14H20N2O2 |
IUPAC name | 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol |
Molecular weight | 248.326 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 3 |
XlogP | 1.8 |
Synonyms | Z3376 NCGC00024925-06 P-6820 Pinbetol Pindolol, European Pharmacopoeia (EP) Reference Standard [ Show all ] |
Inchi Key | JZQKKSLKJUAGIC-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3 |
PubChem CID | 4828 |
ChEMBL | CHEMBL500 |
IUPHAR | 91 |
BindingDB | 50019443 |
DrugBank | DB00960 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
Activity | 64.3 % | PMID21870877 | ChEMBL |
ED50 | 0.0061 mg.kg-1 | PMID2872332 | ChEMBL |
IC50 | 0.921 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Kd | <10000.0 nM | PMID21870877 | BindingDB |
Kd | 2.399 nM | PMID21870877 | ChEMBL |
Kd | 2.4 nM | PMID21870877 | BindingDB |
Kd | 2.6 nM | PMID21870877 | BindingDB |
Kd | 2.63 nM | PMID21870877 | ChEMBL |
Kd | >10000.0 nM | PMID21870877 | ChEMBL |
Ki | 0.52 nM | PMID17804228 | BindingDB,ChEMBL |
Ki | 0.52 nM | PMID17804228 | PDSP,IUPHAR |
Ki | 0.532 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | 1.94 nM | PMID7915318 | PDSP,BindingDB |
Ki | 2.6 nM | PMID14730417 | PDSP,BindingDB |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218