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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameSCHEMBL4802558
Molecular formulaC24H33N3O4S
IUPAC nameN-[5-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl]-2,2-dimethyl-3,4-dihydrochromene-6-sulfonamide
Molecular weight459.605
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP3.7
SynonymsCHEMBL2364453
Inchi KeyAXCLMWWQFJTKNU-CALCHBBNSA-N
Inchi IDInChI=1S/C24H33N3O4S/c1-16-14-27(15-17(2)25-16)19-6-8-23(30-5)21(13-19)26-32(28,29)20-7-9-22-18(12-20)10-11-24(3,4)31-22/h6-9,12-13,16-17,25-26H,10-11,14-15H2,1-5H3/t16-,17+
PubChem CID11576203
ChEMBLCHEMBL2364453
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5031.62 nMDOI: http://dx.doi.org/10.6019/CHEMBL2364335ChEMBL

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