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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL276322
Molecular formula	C23H24ClN3O4S
IUPAC name	1-[2-(5-chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-(2-hydroxy-2-phenylethyl)piperidine-4-carboxamide
Molecular weight	473.972
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.6
Synonyms	BDBM50111650 N-(beta-Hydroxyphenethyl)-1-(2-oxo-5-chloro-2,3-dihydrobenzothiazole-3-ylacetyl)-4-piperidinecarboxamide 1-[2-(5-Chloro-2-oxo-benzothiazol-3-yl)-acetyl]-piperidine-4-carboxylic acid (2-hydroxy-2-phenyl-ethyl)-amide
Inchi Key	AXEBQNVEEPLLRV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H24ClN3O4S/c24-17-6-7-20-18(12-17)27(23(31)32-20)14-21(29)26-10-8-16(9-11-26)22(30)25-13-19(28)15-4-2-1-3-5-15/h1-7,12,16,19,28H,8-11,13-14H2,(H,25,30)
PubChem CID	44271223
ChEMBL	CHEMBL276322
IUPHAR	N/A
BindingDB	50111650
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1.1 nM	PMID11934581	BindingDB,ChEMBL
IC50	1.2 nM	PMID11934581	BindingDB,ChEMBL
Inhibition	47.8 %	PMID11934581	ChEMBL
Inhibition	79.4 %	PMID11934581	ChEMBL
Inhibition	97.1 %	PMID11934581	ChEMBL
Inhibition	107.9 %	PMID11934581	ChEMBL

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