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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameSCHEMBL4802295
Molecular formulaC22H27N3O3S3
IUPAC nameN-[5-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl]-5-(5-methylthiophen-2-yl)thiophene-2-sulfonamide
Molecular weight477.656
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP4.5
SynonymsCHEMBL2364421
Inchi KeyAXIMEHSTRHVITG-GASCZTMLSA-N
Inchi IDInChI=1S/C22H27N3O3S3/c1-14-12-25(13-15(2)23-14)17-6-7-19(28-4)18(11-17)24-31(26,27)22-10-9-21(30-22)20-8-5-16(3)29-20/h5-11,14-15,23-24H,12-13H2,1-4H3/t14-,15+
PubChem CID69197133
ChEMBLCHEMBL2364421
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5025.12 nMDOI: http://dx.doi.org/10.6019/CHEMBL2364335ChEMBL

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