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Name | Metabotropic glutamate receptor 3 |
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Species | Homo sapiens (Human) |
Gene | GRM3 |
Synonym | GPRC1C mGluR3 mGlu3 receptor glutamate receptor |
Disease | Alzheimer disease; Major depressive disorder Anxiety disorder Schizophrenia |
Length | 879 |
Amino acid sequence | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL |
UniProt | Q14832 |
Protein Data Bank | 3sm9, 6b7h, 4xar, 5cnk, 5cnm |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 3sm9. |
BioLiP | BL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561 |
Therapeutic Target Database | T02719 |
ChEMBL | CHEMBL2888 |
IUPHAR | 291 |
DrugBank | N/A |
Name | MGS-0028 |
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Molecular formula | C8H8FNO5 |
IUPAC name | (1R,2S,5S,6S)-2-amino-6-fluoro-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid |
Molecular weight | 217.152 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 3 |
XlogP | -4.2 |
Synonyms | D06SDD (+)-MGS-0028 (1r,2s,5s,6s)-2-amino-6-fluoro-4-oxobicyclo[3.1.0]hexane 2,6-dicarboxylic acid UNII-YMS878LR7I 2-amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid [ Show all ] |
Inchi Key | KFAGJPNFERWZJA-JKBXLQNXSA-N |
Inchi ID | InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1 |
PubChem CID | 9837317 |
ChEMBL | CHEMBL121053 |
IUPHAR | 1395 |
BindingDB | 50094843 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 2.7 nM | PMID12166935 | ChEMBL |
EC50 | 2.07 nM | PMID22318160 | BindingDB,ChEMBL |
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