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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameUrotensin-2 receptor
SpeciesHomo sapiens (Human)
GeneUTS2R
SynonymSENR (sensory epithelial neuropeptide-like receptor)
UII-R1
UT receptor
UR-2-R
UTR2
[ Show all ]
DiseaseAsthma
Diabetic nephropathy
Renal failure
Length389
Amino acid sequenceMALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProtQ9UKP6
Protein Data BankN/A
GPCR-HGmod modelQ9UKP6
3D structure modelThis predicted structure model is from GPCR-EXP Q9UKP6.
BioLiPN/A
Therapeutic Target DatabaseT49072
ChEMBLCHEMBL3764
IUPHAR365
DrugBankN/A

Ligand

NameCHEMBL481129
Molecular formulaC24H31Cl2N3O2
IUPAC name3,4-dichloro-N-[1-[[4-[3-(dimethylamino)propoxy]phenyl]methyl]piperidin-4-yl]benzamide
Molecular weight464.431
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.9
SynonymsSCHEMBL6944245
BDBM50251890
N-(1-(4-(3-(dimethylamino)propoxy)benzyl)piperidin-4-yl)-3,4-dichlorobenzamide
Inchi KeyAXLDTHFWOBTJAN-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H31Cl2N3O2/c1-28(2)12-3-15-31-21-7-4-18(5-8-21)17-29-13-10-20(11-14-29)27-24(30)19-6-9-22(25)23(26)16-19/h4-9,16,20H,3,10-15,17H2,1-2H3,(H,27,30)
PubChem CID18613636
ChEMBLCHEMBL481129
IUPHARN/A
BindingDB50251890
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki500.0 nMPMID18573659BindingDB,ChEMBL

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