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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL181885
Molecular formulaC32H40N4O3
IUPAC name1-N-[2-[di(propan-2-yl)amino]ethyl]-2-N-phenyl-6-phenylmethoxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxamide
Molecular weight528.697
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP5.3
SynonymsN/A
Inchi KeyAXRKVKQBIUAXQE-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H40N4O3/c1-23(2)35(24(3)4)20-18-33-31(37)30-29-16-15-28(39-22-25-11-7-5-8-12-25)21-26(29)17-19-36(30)32(38)34-27-13-9-6-10-14-27/h5-16,21,23-24,30H,17-20,22H2,1-4H3,(H,33,37)(H,34,38)
PubChem CID22888427
ChEMBLCHEMBL181885
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity43.0 %PMID15780609ChEMBL

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