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Name | Free fatty acid receptor 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | FFAR1 |
Synonym | FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor |
Disease | Type 2 diabetes Non-insulin dependent diabetes Diabetes |
Length | 300 |
Amino acid sequence | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK |
UniProt | O14842 |
Protein Data Bank | 5tzy, 5tzr |
GPCR-HGmod model | O14842 |
3D structure model | This structure is from PDB ID 5tzy. |
BioLiP | BL0380462, BL0380463, BL0380464 |
Therapeutic Target Database | T25608 |
ChEMBL | CHEMBL4422 |
IUPHAR | 225 |
DrugBank | BE0000688 |
Name | CHEMBL1777866 |
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Molecular formula | C18H13ClF3NO3 |
IUPAC name | 3-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]hex-4-ynoic acid |
Molecular weight | 383.751 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 4.6 |
Synonyms | BDBM50344073 rac-3-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)hex-4-ynoic acid |
Inchi Key | KJKPJGXGFQYFKV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H13ClF3NO3/c1-2-3-12(8-16(24)25)11-4-6-14(7-5-11)26-17-15(19)9-13(10-23-17)18(20,21)22/h4-7,9-10,12H,8H2,1H3,(H,24,25) |
PubChem CID | 54582630 |
ChEMBL | CHEMBL1777866 |
IUPHAR | N/A |
BindingDB | 50344073 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 108.0 nM | PMID21514824 | BindingDB,ChEMBL |
EC50 | 409.0 nM | PMID21514824 | BindingDB,ChEMBL |
IC50 | 30.0 nM | PMID21514824 | BindingDB,ChEMBL |
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