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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	CHEMBL3701931
Molecular formula	C16H18ClN3O
IUPAC name	N-[(6-chloropyridin-3-yl)methyl]-4-[(2S)-morpholin-2-yl]aniline
Molecular weight	303.79
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.3
Synonyms	US8802673, 32 BDBM129390 SCHEMBL12609757
Inchi Key	KKRDGEPWROLZPG-OAHLLOKOSA-N
Inchi ID	InChI=1S/C16H18ClN3O/c17-16-6-1-12(10-20-16)9-19-14-4-2-13(3-5-14)15-11-18-7-8-21-15/h1-6,10,15,18-19H,7-9,11H2/t15-/m1/s1
PubChem CID	86766833
ChEMBL	CHEMBL3701931
IUPHAR	N/A
BindingDB	129390
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	35.7 nM	, None	BindingDB,ChEMBL

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