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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3641728
Molecular formulaC16H17F3N4O
IUPAC name4-methyl-N-(4-morpholin-2-ylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
Molecular weight338.334
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP2.4
SynonymsBDBM129536
SCHEMBL12609620
US8802673, 178
Inchi KeyKMBUWSMZLJFIOR-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H17F3N4O/c1-10-8-14(16(17,18)19)23-15(21-10)22-12-4-2-11(3-5-12)13-9-20-6-7-24-13/h2-5,8,13,20H,6-7,9H2,1H3,(H,21,22,23)
PubChem CID68325443
ChEMBLCHEMBL3641728
IUPHARN/A
BindingDB129536
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki29.8 nM, NoneBindingDB,ChEMBL

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