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GPCR

NameB2 bradykinin receptor
SpeciesCavia porcellus (Guinea pig)
GeneBDKRB2
SynonymB2R
BK-2 receptor
DiseaseN/A for non-human GPCRs
Length372
Amino acid sequenceMFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGHNVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWARSSSEGTPPGLL
UniProtO70526
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4111
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL156847
Molecular formulaC18H15BrCl3N3O2
IUPAC nameN-[3-[(3-bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]-2,4,6-trichlorophenyl]-N-methylacetamide
Molecular weight491.591
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.9
SynonymsSCHEMBL8564293
BDBM50062888
N-[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4,6-trichloro-phenyl]-N-methyl-acetamide
N-Methyl-N-[2,4,6-trichloro-3-[(2-methyl-3-bromoimidazo[1,2-a]pyridin-8-yl)oxymethyl]phenyl]acetamide
Inchi KeyAYAKZDWRFVQFCP-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H15BrCl3N3O2/c1-9-17(19)25-6-4-5-14(18(25)23-9)27-8-11-12(20)7-13(21)16(15(11)22)24(3)10(2)26/h4-7H,8H2,1-3H3
PubChem CID11799290
ChEMBLCHEMBL156847
IUPHARN/A
BindingDB50062888
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50420.0 nMPMID9484506BindingDB,ChEMBL

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