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GPCR

NameNeuropeptide Y receptor type 2
SpeciesHomo sapiens (Human)
GeneNPY2R
SynonymNPY2-R
NPY-Y2 receptor
neuropeptide Y receptor type 2
Y2 receptor
DiseaseDiabetes
Metabolic disorders
Obesity
Length381
Amino acid sequenceMGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProtP49146
Protein Data BankN/A
GPCR-HGmod modelP49146
3D structure modelThis predicted structure model is from GPCR-EXP P49146.
BioLiPN/A
Therapeutic Target DatabaseT10670
ChEMBLCHEMBL4018
IUPHAR306
DrugBankBE0002419

Ligand

NameMLS000585997
Molecular formulaC22H24N2O3S2
IUPAC nameN-(2,6-diethylphenyl)-2-phenyl-2-(thiophen-2-ylsulfonylamino)acetamide
Molecular weight428.565
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP5.1
SynonymsBDBM42432
N-(2,6-diethylphenyl)-2-phenyl-2-(2-thienylsulfonylamino)acetamide
cid_12005500
N-(2,6-diethylphenyl)-2-phenyl-2-[(thien-2-ylsulfonyl)amino]acetamide
AKOS001795461
[ Show all ]
Inchi KeyAYDCGXFUTQPEON-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H24N2O3S2/c1-3-16-12-8-13-17(4-2)20(16)23-22(25)21(18-10-6-5-7-11-18)24-29(26,27)19-14-9-15-28-19/h5-15,21,24H,3-4H2,1-2H3,(H,23,25)
PubChem CID12005500
ChEMBLCHEMBL1326298
IUPHARN/A
BindingDB42432
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50<35000.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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