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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Ligand

NameCHEMBL117507
Molecular formulaC20H24ClN5O
IUPAC name2-[3-[4-(3-chlorophenyl)piperazin-1-yl]butyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
Molecular weight385.896
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.3
SynonymsBDBM50073443
SCHEMBL9035790
2-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one
Inchi KeyKNYIQWUXTSJAQW-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H24ClN5O/c1-16(8-10-26-20(27)25-9-3-2-7-19(25)22-26)23-11-13-24(14-12-23)18-6-4-5-17(21)15-18/h2-7,9,15-16H,8,10-14H2,1H3
PubChem CID9908172
ChEMBLCHEMBL117507
IUPHARN/A
BindingDB50073443
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition2.0 %PMID9986703ChEMBL

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