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GPCR

NameLutropin-choriogonadotropic hormone receptor
SpeciesHomo sapiens (Human)
GeneLHCGR
Synonymlutropin-choriogonadotropic hormone receptor
Luteinizing hormone receptor
LSH-R
LHR
LH/CG-R
[ Show all ]
DiseaseHeart disease
Breast cancer
Cancer
Myelodysplastic syndrome
Female infertility
[ Show all ]
Length699
Amino acid sequenceMKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
UniProtP22888
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT79473
ChEMBLCHEMBL1854
IUPHARN/A
DrugBankBE0000134

Ligand

NameCHEMBL378091
Molecular formulaC18H20N4O2S2
IUPAC name5-amino-N-tert-butyl-4-(3-hydroxyphenyl)-2-methylsulfanylthieno[2,3-d]pyrimidine-6-carboxamide
Molecular weight388.504
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogP4.2
SynonymsBDBM50189774
KORCEMCZKYMFIO-UHFFFAOYSA-N
tert-Butyl 5-amino-2-methylthio-4-(3-hydroxyphenyl)-thieno[2,3-d]pyrimidine-6-carboxamide
N-tert-butyl-5-amino-4-(3-hydroxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxamide
SCHEMBL4315364
Inchi KeyKORCEMCZKYMFIO-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H20N4O2S2/c1-18(2,3)22-15(24)14-12(19)11-13(9-6-5-7-10(23)8-9)20-17(25-4)21-16(11)26-14/h5-8,23H,19H2,1-4H3,(H,22,24)
PubChem CID11531195
ChEMBLCHEMBL378091
IUPHARN/A
BindingDB50189774
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501900.0 nMPMID16789744BindingDB,ChEMBL
Efficacy63.9 %PMID16789744ChEMBL

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