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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL595715
Molecular formulaC15H17ClN2OS
IUPAC name(2S)-2-(4-chlorophenyl)-3-methyl-N-(4-methyl-1,3-thiazol-2-yl)butanamide
Molecular weight308.824
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.5
Synonyms(2S)-2-(4-chlorophenyl)-3-methyl-N-(4-methyl-1,3-thiazol-2-yl)butanamide
(S)-2-(4-chlorophenyl)-3-methyl-N-(4-methylthiazol-2-yl)butanamide
AC1PKTEA
BDBM50305969
ZINC7968945
Inchi KeyKOXXJBZZVATNHN-ZDUSSCGKSA-N
Inchi IDInChI=1S/C15H17ClN2OS/c1-9(2)13(11-4-6-12(16)7-5-11)14(19)18-15-17-10(3)8-20-15/h4-9,13H,1-3H3,(H,17,18,19)/t13-/m0/s1
PubChem CID9095896
ChEMBLCHEMBL595715
IUPHARN/A
BindingDB50305969
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy87.0 %PMID20005104ChEMBL
IC501400.0 nMPMID20005104BindingDB,ChEMBL

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