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GPCR

NameGrowth hormone-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGhrhr
SynonymGhrfr
GHRH receptor
GRF receptor
GRFR
Growth hormone-releasing factor receptor
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProtQ02644
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3709
IUPHARN/A
DrugBankN/A

Ligand

NameBDBM50004980
Molecular formulaC144H238N42O40S
IUPAC name(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
Molecular weight3229.8
Hydrogen bond acceptor47
Hydrogen bond donor50
XlogP-10.7
SynonymsN/A
Inchi KeyKPFROLPOEURUKX-KQPSSKJFSA-N
Inchi IDInChI=1S/C144H238N42O40S/c1-20-75(13)112(184-118(203)79(17)162-127(212)101(64-109(196)197)171-117(202)77(15)161-119(204)86(147)60-82-39-43-84(191)44-40-82)140(225)178-99(61-81-32-23-22-24-33-81)133(218)186-114(80(18)190)141(226)179-100(63-107(149)194)132(217)182-105(69-189)137(222)175-98(62-83-41-45-85(192)46-42-83)131(216)169-91(38-31-54-159-144(155)156)122(207)168-89(35-26-28-51-146)126(211)183-111(74(11)12)138(223)177-94(56-70(3)4)120(205)160-66-108(195)164-92(47-48-106(148)193)124(209)173-97(59-73(9)10)130(215)181-103(67-187)135(220)163-78(16)116(201)166-90(37-30-53-158-143(153)154)121(206)167-88(34-25-27-50-145)123(208)172-95(57-71(5)6)128(213)174-96(58-72(7)8)129(214)176-102(65-110(198)199)134(219)185-113(76(14)21-2)139(224)170-93(49-55-227-19)125(210)180-104(68-188)136(221)165-87(115(150)200)36-29-52-157-142(151)152/h22-24,32-33,39-46,70-80,86-105,111-114,187-192H,20-21,25-31,34-38,47-69,145-147H2,1-19H3,(H2,148,193)(H2,149,194)(H2,150,200)(H,160,205)(H,161,204)(H,162,212)(H,163,220)(H,164,195)(H,165,221)(H,166,201)(H,167,206)(H,168,207)(H,169,216)(H,170,224)(H,171,202)(H,172,208)(H,173,209)(H,174,213)(H,175,222)(H,176,214)(H,177,223)(H,178,225)(H,179,226)(H,180,210)(H,181,215)(H,182,217)(H,183,211)(H,184,203)(H,185,219)(H,186,218)(H,196,197)(H,198,199)(H4,151,152,157)(H4,153,154,158)(H4,155,156,159)/t75-,76-,77-,78-,79-,80+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,111-,112-,113-,114-/m0/s1
PubChem CID91928703
ChEMBLCHEMBL262536
IUPHARN/A
BindingDB50004980
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity12.0 %PMID1534126ChEMBL
IC5045.2 nMPMID1534126BindingDB,ChEMBL

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