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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Growth hormone-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Ghrhr
Synonym	Ghrfr GHRH receptor GRF receptor GRFR Growth hormone-releasing factor receptor
Disease	N/A for non-human GPCRs
Length	464
Amino acid sequence	MDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProt	Q02644
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3709
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL538004
Molecular formula	C33H46ClN3O4
IUPAC name	ethyl 3-[1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propanoate;hydrochloride
Molecular weight	584.198
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	None
Synonyms	SCHEMBL8313866
Inchi Key	KPTRVSSAAPWEMT-GYMGLUJESA-N
Inchi ID	InChI=1S/C33H45N3O4.ClH/c1-4-40-29(37)18-17-25-23-33(27-15-9-8-14-26(25)27)19-21-36(22-20-33)30(38)28(35-31(39)32(2,3)34)16-10-13-24-11-6-5-7-12-24;/h5-9,11-12,14-15,25,28H,4,10,13,16-23,34H2,1-3H3,(H,35,39);1H/t25?,28-;/m1./s1
PubChem CID	45264542
ChEMBL	CHEMBL538004
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.3 nM	Bioorg. Med. Chem. Lett., (1997) 7:17:2319	ChEMBL

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