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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701942
Molecular formulaC15H16FN3O
IUPAC name5-fluoro-N-[4-[(2S)-morpholin-2-yl]phenyl]pyridin-3-amine
Molecular weight273.311
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP1.5
SynonymsSCHEMBL12610168
BDBM129401
US8802673, 43
Inchi KeyKQAIOWLBUNCCPB-OAHLLOKOSA-N
Inchi IDInChI=1S/C15H16FN3O/c16-12-7-14(9-18-8-12)19-13-3-1-11(2-4-13)15-10-17-5-6-20-15/h1-4,7-9,15,17,19H,5-6,10H2/t15-/m1/s1
PubChem CID68325813
ChEMBLCHEMBL3701942
IUPHARN/A
BindingDB129401
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki648.4 nM, NoneBindingDB,ChEMBL

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