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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL203637 |
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Molecular formula | C18H20ClNO |
IUPAC name | 7-chloro-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-ol |
Molecular weight | 301.814 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 4.4 |
Synonyms | 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-ol 4-Chloro-3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine BDBM50184428 |
Inchi Key | KRGBBAYNHOEQOO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H20ClNO/c1-20-10-8-13-4-2-3-5-14(13)12-15-6-7-17(21)18(19)16(15)9-11-20/h2-7,21H,8-12H2,1H3 |
PubChem CID | 11681599 |
ChEMBL | CHEMBL203637 |
IUPHAR | N/A |
BindingDB | 50184428 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 3.548 nM | PMID18534847 | ChEMBL |
Ki | 3.55 nM | PMID18534847 | BindingDB |
Ki | 4.0 nM | PMID16539400 | BindingDB,ChEMBL |
Ki | 6.1 nM | PMID16539400 | BindingDB,ChEMBL |
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