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GLASS

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GPCR

Name	Metabotropic glutamate receptor 2
Species	Rattus norvegicus (Rat)
Gene	Grm2
Synonym	glutamate receptor GPRC1B metabotropic glutamate receptor 2 mGlu2 receptor mGluR2
Disease	N/A for non-human GPCRs
Length	872
Amino acid sequence	MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProt	P31421
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2851
IUPHAR	290
DrugBank	N/A

Ligand

Name	(2S,4R)-4-Methylglutamic acid
Molecular formula	C6H11NO4
IUPAC name	(2S,4R)-2-amino-4-methylpentanedioic acid
Molecular weight	161.157
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-2.9
Synonyms	(2S, 4R)-4-methyl glutamic acid 14561-55-8 AC1L3VAT J-018254 SR-01000597438 (2S,4R)-2-amino-4-methylpentanedioic acid 31137-74-3 BDBM50031704 D0B2VW MolPort-003-848-893 sym 2081 (2S,4R)-4-Methylglutamic acid, solid C-35651 Glutamic acid, 4-methyl- (VAN) NSC 41355 Tocris-0903 (2S,4R)-(+)-2-AMINO-4-METHYLPENTANEDIOIC ACID 2-Amino-4-methyl-pentanedioic acid AC1Q5QI2 CHEMBL288166 KRKRAOXTGDJWNI-DMTCNVIQSA-N SR-01000597438-1 (2S,4R)-4-methyl glutamic acid 4-Methylglutamate Biomol-NT_000218 FCH842663 NCGC00024860-01 SYM-2081 (4r)-4-methyl-l-glutamic acid 59685-03-9 CC-00464 I04-1512 SCHEMBL594187 ZINC896091 (2S,4R)-2-Amino-4-methyl-pentanedioic acid 2S,4R-4-Methylglutamate AKOS006273726 CTK5B0310 MFCD00937765 SYM 4-Methylglutamic acid BPBio1_001308 FT-0604674 NCGC00024860-02 threo-gamma-Methylglutamate [ Show all ]
Inchi Key	KRKRAOXTGDJWNI-DMTCNVIQSA-N
Inchi ID	InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
PubChem CID	95883
ChEMBL	CHEMBL288166
IUPHAR	N/A
BindingDB	50031704
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50 ratio	23.0 -	PMID10229625	ChEMBL

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