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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Mus musculus (Mouse)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	440
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN
UniProt	Q9R1C8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075268
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	RU 24969
Molecular formula	C14H16N2O
IUPAC name	5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
Molecular weight	228.295
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.8
Synonyms	5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole(RU-24969) AC1Q4F1Q FT-0745673 NCGC00024867-01 ZINC2568243 2ISE72RACC 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole BDBM81498 CTK1J4546 KRVMLPUDAOWOGN-UHFFFAOYSA-N NSC_108028 SCHEMBL2359264 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1h-indole AB00698348-04 CAS_108028 DTXSID40276045 MCULE-3532976182 PDSP2_001601 Tocris-0912 1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)- 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole AKOS005135871 CHEMBL18785 GTPL23 NCGC00024867-02 RU-24,969 3-(1,2,3,6-tetrahydropyridin-4-yl)-5-methoxy-1H-indole 66611-26-5 Biomol-NT_000116 D03PJW L001328 PDSP1_001617 SR-01000597981 5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole AC1L337E CHEBI:92005 EN300-39806 MolPort-003-983-322 PDSP2_001607 UNII-2ISE72RACC 5-methoxy-3-(1,2,3,6-tetrahydropyridine-4-yl)-1H-indole API0006969 CS-3218 HY-16688 NE18708 RU-24969 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole BPBio1_000177 DB-073775 LS-187325 PDSP1_001623 SR-01000597981-1 [ Show all ]
Inchi Key	KRVMLPUDAOWOGN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3
PubChem CID	108029
ChEMBL	CHEMBL18785
IUPHAR	23
BindingDB	81498
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	125.89 nM	PMID8394987	BindingDB

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