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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Mus musculus (Mouse)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProt	Q62035
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3993
IUPHAR	334
DrugBank	N/A

Ligand

Name	CID 15005334
Molecular formula	C33H32ClN5O3
IUPAC name	ethyl 4-(2-chlorophenyl)-6-methyl-5-(pyridin-2-ylcarbamoyl)-2-[4-(2,4,5-trimethylimidazol-1-yl)phenyl]-1,4-dihydropyridine-3-carboxylate
Molecular weight	582.101
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	6.0
Synonyms	N/A
Inchi Key	KSAZWYFJLZNXHL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C33H32ClN5O3/c1-6-42-33(41)30-29(25-11-7-8-12-26(25)34)28(32(40)38-27-13-9-10-18-35-27)20(3)37-31(30)23-14-16-24(17-15-23)39-21(4)19(2)36-22(39)5/h7-18,29,37H,6H2,1-5H3,(H,35,38,40)
PubChem CID	15005334
ChEMBL	CHEMBL323290
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
ED50	10.5 mg.kg-1	PMID1507200	ChEMBL

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