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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

Namecarboxylic acid agonist, 20
Molecular formulaC23H21NO2
IUPAC name2-[4-[(4-phenylphenyl)methylamino]phenyl]cyclopropane-1-carboxylic acid
Molecular weight343.426
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP4.7
SynonymsCHEMBL234450
SCHEMBL13043487
BDBM22503
2-(4-{[(4-phenylphenyl)methyl]amino}phenyl)cyclopropane-1-carboxylic acid
Inchi KeyAYQLRMNZMKEEKX-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H21NO2/c25-23(26)22-14-21(22)19-10-12-20(13-11-19)24-15-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-13,21-22,24H,14-15H2,(H,25,26)
PubChem CID24825485
ChEMBLCHEMBL234450
IUPHARN/A
BindingDB22503
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
%max80.0 %PMID17240142ChEMBL
EC5039.81 nMPMID17240142ChEMBL
EC5040.0 nMPMID17240142BindingDB

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