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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL523835
Molecular formulaC14H19N7O
IUPAC name4-(2-methoxypyrimidin-5-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Molecular weight301.354
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP0.4
SynonymsSCHEMBL2166257
Inchi KeyKSQVGLYYIJALAS-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H19N7O/c1-20-3-5-21(6-4-20)12-7-11(18-13(15)19-12)10-8-16-14(22-2)17-9-10/h7-9H,3-6H2,1-2H3,(H2,15,18,19)
PubChem CID25131557
ChEMBLCHEMBL523835
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC503235.94 nMPMID18811133ChEMBL
Efficacy53.0 %PMID18811133ChEMBL

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