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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL2159334
Molecular formula	C28H22Cl2F3N3O4
IUPAC name	3-[[4-[1-[3-(3,5-dichlorophenyl)-5-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acid
Molecular weight	592.396
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	6.8
Synonyms	BDBM50393773
Inchi Key	AYWGEISQTISXEW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H22Cl2F3N3O4/c1-16(17-2-4-19(5-3-17)27(39)34-11-10-26(37)38)36-25(18-6-8-23(9-7-18)40-28(31,32)33)15-24(35-36)20-12-21(29)14-22(30)13-20/h2-9,12-16H,10-11H2,1H3,(H,34,39)(H,37,38)
PubChem CID	60170854
ChEMBL	CHEMBL2159334
IUPHAR	N/A
BindingDB	50393773
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	77.5 nM	PMID22708876	ChEMBL
IC50	78.0 nM	PMID22708876	BindingDB
IC50	100.0 nM	PMID22708876	BindingDB
IC50	100.3 nM	PMID22708876	ChEMBL

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