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GPCR

NameMuscarinic acetylcholine receptor M4
SpeciesRattus norvegicus (Rat)
GeneChrm4
Synonymcholinergic receptor
cholinergic receptor, muscarinic 4
Chrm-4
HM3
M4 receptor
DiseaseN/A for non-human GPCRs
Length478
Amino acid sequenceMXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProtP08485
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL317
IUPHAR16
DrugBankN/A

Ligand

NameCHEMBL1202054
Molecular formulaC24H40N4O8
IUPAC nametert-butyl N-[2-[[6-[methyl(4-pyrrolidin-1-ylbut-2-ynyl)amino]-6-oxohexyl]amino]-2-oxoethyl]carbamate;oxalic acid
Molecular weight512.604
Hydrogen bond acceptor9
Hydrogen bond donor4
XlogPNone
SynonymsN/A
Inchi KeyKUNDKPWRJUXNFL-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H38N4O4.C2H2O4/c1-22(2,3)30-21(29)24-18-19(27)23-13-7-5-6-12-20(28)25(4)14-8-9-15-26-16-10-11-17-26;3-1(4)2(5)6/h5-7,10-18H2,1-4H3,(H,23,27)(H,24,29);(H,3,4)(H,5,6)
PubChem CID49859885
ChEMBLCHEMBL1202054
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Activity>1.0 %PMID2153827ChEMBL
Affinity52.3 %PMID2153827ChEMBL

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