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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Sus scrofa (Pig)
Gene	CHRM2
Synonym	N/A
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P06199
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4781
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL274564
Molecular formula	C40H54Br2N4O4
IUPAC name	[3-(1,3-dioxobenzo[de]isoquinolin-2-yl)-2,2-dimethylpropyl]-[6-[[3-(1,3-dioxoisoindol-2-yl)-2,2-dimethylpropyl]-dimethylazaniumyl]hexyl]-dimethylazanium;dibromide
Molecular weight	814.704
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	None
Synonyms	N/A
Inchi Key	KYNMWSRJPWQATB-UHFFFAOYSA-L
Inchi ID	InChI=1S/C40H54N4O4.2BrH/c1-39(2,25-41-35(45)30-19-11-12-20-31(30)36(41)46)27-43(5,6)23-13-9-10-14-24-44(7,8)28-40(3,4)26-42-37(47)32-21-15-17-29-18-16-22-33(34(29)32)38(42)48;;/h11-12,15-22H,9-10,13-14,23-28H2,1-8H3;2*1H/q+2;;/p-2
PubChem CID	11828872
ChEMBL	CHEMBL274564
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
-logKa	7.41 -	PMID12620079	ChEMBL
EC50	18.62 nM	PMID12620079	ChEMBL
p alpha	0.56 -	PMID15771463	ChEMBL
p alphaKa	7.97 -	PMID12620079	ChEMBL
pAlpha	0.56 -	PMID12620079	ChEMBL
pEC50 diss	7.73 -	PMID15771463	ChEMBL
pKA	7.41 -	PMID15771463	ChEMBL

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