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GPCR

NameGlucagon-like peptide 1 receptor
SpeciesRattus norvegicus (Rat)
GeneGlp1r
SynonymGLP-1 receptor
GLP-1-R
GLP-1R
glucagon-like peptide 1 receptor
DiseaseN/A for non-human GPCRs
Length463
Amino acid sequenceMAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
UniProtP32301
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5862
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2158415
Molecular formulaC28H28N2O8S
IUPAC name(1R,2R)-2-[3-methoxy-4-(thiophene-2-carbonyloxy)phenyl]-1-[[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]amino]cyclopropane-1-carboxylic acid
Molecular weight552.598
Hydrogen bond acceptor9
Hydrogen bond donor3
XlogP4.5
SynonymsBDBM50393579
Inchi KeyLBOBTSAFAAPCBZ-WHLCRQNOSA-N
Inchi IDInChI=1S/C28H28N2O8S/c1-27(2,3)38-26(35)29-18-10-7-16(8-11-18)23(31)30-28(25(33)34)15-19(28)17-9-12-20(21(14-17)36-4)37-24(32)22-6-5-13-39-22/h5-14,19H,15H2,1-4H3,(H,29,35)(H,30,31)(H,33,34)/t19-,28-/m1/s1
PubChem CID71451370
ChEMBLCHEMBL2158415
IUPHARN/A
BindingDB50393579
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50<20000.0 nMPMID22103243BindingDB,ChEMBL
Efficacy>15.0 %PMID22103243ChEMBL
IC50<20000.0 nMPMID22103243BindingDB,ChEMBL
Inhibition>15.0 %PMID22103243ChEMBL

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